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Simultaneous inhibition of LSD1 and TGFβ enables eradication of poorly immunogenic tumors with Anti-PD-1 treatment

Abstract:

Epigenetic regulators are a class of promising targets in combination with immune checkpoint inhibitors for cancer treatment, but the impact of the broad effects of perturbing epigenetic regulators on tumor immunotherapy remains to be fully explored. Here we show that ablation of the histone demethylase LSD1 in multiple tumor cells induces TGFβ expression, which exerts an inhibitory effect on T-cell immunity through suppressing the cytotoxicity of intratumoral CD8+ T cells and consequently da...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1158/2159-8290.cd-20-0017

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
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Name:
HHS | National Institutes of Health
Publisher:
American Association for Cancer Research
Journal:
Cancer Discovery More from this journal
Volume:
11
Issue:
8
Pages:
1970-1981
Publication date:
2021-03-09
Acceptance date:
2021-03-04
DOI:
EISSN:
2159-8290
ISSN:
2159-8274
Pmid:
33687985
Language:
English
Keywords:
Subtype:
Comment
Pubs id:
1187230
Local pid:
pubs:1187230
Deposit date:
2021-11-18

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