Journal article : Comment
Simultaneous inhibition of LSD1 and TGFβ enables eradication of poorly immunogenic tumors with Anti-PD-1 treatment
- Abstract:
-
Epigenetic regulators are a class of promising targets in combination with immune checkpoint inhibitors for cancer treatment, but the impact of the broad effects of perturbing epigenetic regulators on tumor immunotherapy remains to be fully explored. Here we show that ablation of the histone demethylase LSD1 in multiple tumor cells induces TGFβ expression, which exerts an inhibitory effect on T-cell immunity through suppressing the cytotoxicity of intratumoral CD8+ T cells and consequently da...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
HHS | National Institutes of Health
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Bibliographic Details
- Publisher:
- American Association for Cancer Research Publisher's website
- Journal:
- Cancer Discovery Journal website
- Volume:
- 11
- Issue:
- 8
- Pages:
- 1970-1981
- Publication date:
- 2021-03-09
- Acceptance date:
- 2021-03-04
- DOI:
- EISSN:
-
2159-8290
- ISSN:
-
2159-8274
- Pmid:
-
33687985
Item Description
- Language:
- English
- Keywords:
- Subtype:
- Comment
- Pubs id:
-
1187230
- Local pid:
- pubs:1187230
- Deposit date:
- 2021-11-18
Terms of use
- Copyright holder:
- American Association for Cancer Research
- Copyright date:
- 2021
- Rights statement:
- © 2021 American Association for Cancer Research
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from American Association for Cancer Research at: https://doi.org/10.1158/2159-8290.CD-20-0017
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