- Abstract:
-
AMP-activated protein kinase has been shown to be a key regulator of energy homeostasis; it has also been identified as a tumor suppressor and is required for correct cell division and chromosome segregation during mitosis. The enzyme is a heterotrimer, with each subunit having more than one isoform, each encoded by a separate gene (two α, two β and three γ isoforms). In human endothelial cells, the activated kinase subunit of AMPK in the cytokinetic apparatus is α2, the minority α subunit, w...
Expand abstract - Publisher copy:
- 10.4161/cc.11.5.19412
-
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- Journal:
- Cell cycle (Georgetown, Tex.)
- Volume:
- 11
- Issue:
- 5
- Pages:
- 917-921
- Publication date:
- 2012-03-05
- DOI:
- EISSN:
-
1551-4005
- ISSN:
-
1538-4101
- URN:
-
uuid:0c3ef2bc-697b-4023-81dc-85f50da0e10f
- Source identifiers:
-
312920
- Local pid:
- pubs:312920
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Subunit composition of AMPK trimers present in the cytokinetic apparatus: Implications for drug target identification.
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