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Subunit composition of AMPK trimers present in the cytokinetic apparatus: Implications for drug target identification.

Abstract:

AMP-activated protein kinase has been shown to be a key regulator of energy homeostasis; it has also been identified as a tumor suppressor and is required for correct cell division and chromosome segregation during mitosis. The enzyme is a heterotrimer, with each subunit having more than one isoform, each encoded by a separate gene (two α, two β and three γ isoforms). In human endothelial cells, the activated kinase subunit of AMPK in the cytokinetic apparatus is α2, the minority α subunit, w...

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Publisher copy:
10.4161/cc.11.5.19412

Authors


Jefferson, A More by this author
Watkins, H More by this author
Redwood, C More by this author
Journal:
Cell cycle (Georgetown, Tex.)
Volume:
11
Issue:
5
Pages:
917-921
Publication date:
2012-03-05
DOI:
EISSN:
1551-4005
ISSN:
1538-4101
URN:
uuid:0c3ef2bc-697b-4023-81dc-85f50da0e10f
Source identifiers:
312920
Local pid:
pubs:312920

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