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Journal article

Low affinity antibodies against collagen type II are associated with pathology in collagen-induced arthritis in mice.

Abstract:

The relationship between the functional affinity of antibodies against type II collagen (CII) and the development of arthritis was studied in mice with collagen-induced arthritis. The responses of DBA/1 strain mice were compared with those of mice selectively bred to produce antibodies of high functional affinity (HA mice) and low functional affinity (LA mice). HA and LA mice did not develop arthritis in response to immunization with CII whereas 86% of DBA/1 mice did, with 33% showing severe ...

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Publication status:
Published

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Journal:
Journal of autoimmunity More from this journal
Volume:
3
Issue:
6
Pages:
643-657
Publication date:
1990-12-01
DOI:
EISSN:
1095-9157
ISSN:
0896-8411
Language:
English
Keywords:
Pubs id:
pubs:110488
UUID:
uuid:0c3ebb15-25a8-418c-a3ce-703e4a5d172e
Local pid:
pubs:110488
Source identifiers:
110488
Deposit date:
2012-12-19

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