Targeting a host process as an antiviral approach against dengue virus

Journal article

The re-emergence of dengue virus as a significant human pathogen has lead to an increasing need for effective antivirals. Development of therapeutic agents with the ability to attenuate both the duration and severity of disease in patients after infection is particularly desirable in dengue endemic resource-poor settings. The reliance of dengue virus on endogenous processes during the late stages of infection prompts the development of molecules to interfere with and exploit these dependencies as potential antiviral therapies. Here we focus on the importance of N-linked glycan processing in infectious virion morphogenesis.

Authors: Sayce, A; Miller, J; Zitzmann, N

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Cell Press
• Journal: Trends in Microbiology
• Volume: 18
• Issue: 7
• Pages: 323-330
• Publication date: 2010-05-06
• Acceptance date: 2010-04-12
• DOI: 10.1016/j.tim.2010.04.003
• EISSN: 1878-4380
• ISSN: 0966-842X
• Language: English
• Keywords: Cell Line; Host-Pathogen Interactions; Models, Biological; Antiviral Agents; Protein Processing, Post-Translational; Glycosylation; Enzyme Inhibitors; Cricetinae; Inhibitory Concentration 50; Dengue; Humans; Dengue Virus; Viral Proteins; Animals