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Journal article

Genetic influences in end-stage osteoarthritis. Sibling risks of hip and knee replacement for idiopathic osteoarthritis.

Abstract:

From a prospective, cross-sectional survey of 402 patients who had a total hip (THR) or a total knee (TKR) replacement for idiopathic osteoarthritis (OA) at a major centre, we determined the prevalence of these replacements for idiopathic OA in their 1171 siblings and 376 spouses. Using spouses as controls, the relative risk of THR in siblings was 1.86 (95% CI 0.93 to 3.69). The relative risk for TKR in siblings v spouses was 4.8 (95 % CI 0.64 to 36.4) whereas the risk for the combined outcom...

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Publication status:
Published

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Publisher copy:
10.1302/0301-620x.79b4.7437

Authors


Chitnavis, J More by this author
Sinsheimer, JS More by this author
Clipsham, K More by this author
Loughlin, J More by this author
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Journal:
The Journal of bone and joint surgery. British volume
Volume:
79
Issue:
4
Pages:
660-664
Publication date:
1997-07-05
DOI:
ISSN:
0301-620X
URN:
uuid:0c25a65a-ec5c-4cbf-ace5-2890a81cc3b5
Source identifiers:
103930
Local pid:
pubs:103930

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