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Journal article

Population pharmacokinetic model and meta-analysis of outcomes of amphotericin B deoxycholate use in adults with cryptococcal meningitis

Abstract:

There is a limited understanding of the population pharmacokinetics (PK) and pharmacodynamics (PD) of amphotericin B deoxycholate (DAmB) for cryptococcal meningitis (CM). A PK study was conducted in n=42 patients receiving DAmB 1 mg/kg q24h. A 2-compartment PK model was developed. Patient weight influenced clearance and volume in the final structural model. Monte Carlo simulations estimated drug exposure associated with various DAmB dosages. A search was conducted for trials reporting outc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/AAC.02526-17

Authors


More from this funder
Name:
Medical Research Council
Grant:
G1100684/1
More from this funder
Name:
Department for International Development
Grant:
G1100684/1
More from this funder
Name:
Wellcome Trust
Grant:
097147/Z/11/Z
WT097147MA
Publisher:
American Society for Microbiology
Journal:
Antimicrobial Agents and Chemotherapy More from this journal
Volume:
62
Issue:
7
Pages:
e02526-17
Publication date:
2018-05-07
Acceptance date:
2018-04-27
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Keywords:
Pubs id:
pubs:844960
UUID:
uuid:0c234ff9-eed2-4c98-8a1e-c36538c7428f
Local pid:
pubs:844960
Source identifiers:
844960
Deposit date:
2018-05-09

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