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Journal article

Diminished frequency of hepatitis C virus specific interferon gamma secreting CD4+ T cells in human immunodeficiency virus/hepatitis C virus coinfected patients.

Abstract:

BACKGROUND: Human immunodeficiency virus/hepatitis C virus (HIV/HCV) coinfection is a common and complex clinical problem in which loss of immunological control of HCV occurs, with increased HCV viral load and more aggressive liver disease. Cellular immune responses, particularly secretion of interferon gamma (IFN-gamma) appear to be important in the control of HCV, and a detectable HCV specific CD4 response is associated with clearance of the virus. HCV specific CD8+ T cell responses, weak i...

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Publication status:
Published

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Publisher copy:
10.1136/gut.2005.083758

Authors


Harcourt, G More by this author
Gomperts, E More by this author
Donfield, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Journal:
Gut
Volume:
55
Issue:
10
Pages:
1484-1487
Publication date:
2006-10-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:0c2275ae-0ee8-408a-8093-bd80392a4ba5
Source identifiers:
30383
Local pid:
pubs:30383

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