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A study of the effect of general anesthetics on lipid-protein interactions in acetylcholine receptor enriched membranes from Torpedo nobiliana using nitroxide spin-labels.

Abstract:

Stearic acid, phosphatidylcholine, and phosphatidylglycerol nitroxide spin-labels were used to probe the effect of 1-hexanol, urethane, diethyl ether, and ethanol on lipid-protein interactions in nicotinic acetylcholine receptor (nAcChoR) rich membranes from Torpedo nobiliana. For stearic acid spin-labeled at the C-14 position of the sn-1 acyl chain, 1-hexanol induced little change (over a wide concentration range, 0-16.7 mM) in either the ESR line shape or the proportion of motionally restri...

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Publication status:
Published

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Publisher copy:
10.1021/bi00463a007

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Biochemistry More from this journal
Volume:
29
Issue:
11
Pages:
2664-2669
Publication date:
1990-03-01
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
Language:
English
Keywords:
Pubs id:
pubs:170086
UUID:
uuid:0c200feb-f445-4bbc-808c-4d032dd74c4f
Local pid:
pubs:170086
Source identifiers:
170086
Deposit date:
2013-11-17

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