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Association Between Pathogens Detected Using Quantitative Polymerase Chain Reaction With Airway Inflammation in COPD at Stable State and Exacerbations.

Abstract:

BACKGROUND: Relationships between airway inflammation and respiratory potentially pathogenic microorganisms (PPMs) quantified using quantitative polymerase chain reaction (qPCR) in subjects with COPD are unclear. Our aim was to evaluate mediators of airway inflammation and their association with PPMs in subjects with COPD at stable state and during exacerbations. METHODS: Sputum from 120 stable subjects with COPD was analyzed for bacteriology (colony-forming units; total 16S; and qPCR targeti...

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Publication status:
Published

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Publisher copy:
10.1378/chest.14-0764

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Publisher:
American College of Chest Physicians
Journal:
Chest
Volume:
147
Issue:
1
Pages:
46-55
Publication date:
2015-01-05
DOI:
EISSN:
1931-3543
ISSN:
0012-3692
URN:
uuid:0c1305cf-9dfc-496d-9de7-e82f18bb4def
Source identifiers:
480113
Local pid:
pubs:480113
Language:
English

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