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T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells.

Abstract:

CD4(+)CD25(+) regulatory T (T reg) cells play a pivotal role in control of the immune response. Transforming growth factor-beta (TGF-beta) has been shown to be required for T reg cell activity; however, precisely how it is involved in the mechanism of suppression is poorly understood. Using the T cell transfer model of colitis, we show here that CD4(+)CD45RB(high) T cells that express a dominant negative TGF-beta receptor type II (dnTbetaRII) and therefore cannot respond to TGF-beta, escape c...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20040685

Authors


Fahlén, L More by this author
Gorelik, L More by this author
Coffman, RL More by this author
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Journal:
The Journal of experimental medicine
Volume:
201
Issue:
5
Pages:
737-746
Publication date:
2005-03-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:0c12b9c3-8b52-47fd-9d0a-aa8b413cecd7
Source identifiers:
18627
Local pid:
pubs:18627

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