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Journal article

Relaxed DM requirements during class II peptide loading and CD4+ T cell maturation in BALB/c mice.

Abstract:

Current ideas about DM actions have been strongly influenced by studies of mutant strains expressing the H-2(b) haplotype. To evaluate DM contributions to class II activities in BALB/c mice, we generated a novel mutation at the DMa locus via embryonic stem cell technology. Unlike long-lived A(b)/class II-associated invariant chain-derived peptide (CLIP) complexes, mature A(d) and E(d) molecules are loosely occupied by class II-associated invariant chain-derived peptide and are SDS unstable. B...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.166.8.5087

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of Immunology More from this journal
Volume:
166
Issue:
8
Pages:
5087-5098
Publication date:
2001-04-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767

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