Relaxed DM requirements during class II peptide loading and CD4+ T cell maturation in BALB/c mice.

Journal article

Current ideas about DM actions have been strongly influenced by studies of mutant strains expressing the H-2(b) haplotype. To evaluate DM contributions to class II activities in BALB/c mice, we generated a novel mutation at the DMa locus via embryonic stem cell technology. Unlike long-lived A(b)/class II-associated invariant chain-derived peptide (CLIP) complexes, mature A(d) and E(d) molecules are loosely occupied by class II-associated invariant chain-derived peptide and are SDS unstable. B...

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Authors: Bikoff, E; Wutz, G; Kenty, G; Koonce, C; Robertson, E

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 166
• Issue: 8
• Pages: 5087-5098
• Publication date: 2001-04-01
• DOI: 10.4049/jimmunol.166.8.5087
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Cell Line; Mice, Inbred BALB C; Antigens, Differentiation, B-Lymphocyte; Male; Peptides; Female; Clone Cells; Crosses, Genetic; Gene Targeting; Cell Differentiation; Sequence Deletion; Mice, Inbred C57BL; CD4-Positive T-Lymphocytes; Lymphocyte Activation; Histocompatibility Antigens Class II; Protein Conformation; Mice; Dimerization; Antigen Presentation; Alleles; Sodium Dodecyl Sulfate; Mice, Inbred DBA; Mice, Knockout; Haplotypes; Animals