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Immunogenicity and induction of immunological memory of the heptavalent pneumococcal conjugate vaccine in preterm UK infants

Abstract:

Data on the immunogenicity and memory induction of pneumococcal conjugate vaccines in very preterm infants is limited. We vaccinated 69 full term and 68 preterm infants (median gestational age (GA) 30 weeks) with a 7-valent pneumococcal conjugate vaccine (PCV7) at 2/3/4 months of age, followed by a plain polysaccharide booster at 12 months of age. IgG-GMC (ELISA) was significantly lower in preterm infants to six vaccine serotypes (ST) at 2 months and 5 months of age, to five ST at 12 months o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
"St George's University of London, UK", "University Children's Hospital, Düsseldorf, Germany"
Department:
Paediatric Infectious Diseases,Department of General Paediatrics
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Institution:
University of Oxford
Research group:
Oxford Vaccine Group
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Institution:
"Hope Hospital, Salford, UK"
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Institution:
"St George's University of London"
Department:
Division of Child Health and Vaccine Institute
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Institution:
"St George's University of London"
Department:
Division of Child Health and Vaccine Institute
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Wyeth Vaccines More from this funder
Publisher:
Elsevier Ltd. Publisher's website
Journal:
Vaccine Journal website
Volume:
25
Issue:
2
Pages:
264-271
Publication date:
2007-01-05
DOI:
ISSN:
0264-410X
URN:
uuid:0c0fc5d8-fc64-4f43-ab66-252fa85620cc
Local pid:
ora:3196

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