Journal article icon

Journal article

N1...N3 hydrogen bonds of A:U base pairs of RNA are stronger than those of A:T base pairs of DNA.

Abstract:
Trans-hydrogen-bond deuterium isotope effects of Watson-Crick A:U and A:T base pairs of 10 homologous RNA and DNA duplexes are compared. The isotope effect at 13C2 of adenosine residues due to deuterium/protium substitution at the imino H3 site, 2hDelta13C2, is larger in RNA than in DNA. The virtually consistent larger isotope effects in RNA suggest that the N1...N3 hydrogen bonds of A:U base pairs of RNA are stronger than those of the A:T base pairs of DNA.

Actions


Access Document


Publisher copy:
10.1021/ja048981t

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
LiWang, AC More by this author
Journal:
J Am Chem Soc
Volume:
126
Issue:
18
Pages:
5688-5689
Publication date:
2004-05-12
DOI:
ISSN:
0002-7863
URN:
uuid:0c0ef1bb-3ed8-429b-b053-2c1e5fc80b96
Source identifiers:
196795
Local pid:
pubs:196795

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP