Markers of platelet activation and apoptosis during storage of apheresis- and buffy coat-derived platelet concentrates for 7 days.

Journal article

BACKGROUND: The different production methods for platelet concentrates (PCs) result in products with variable in vitro quality and in vivo viability. The aim of this study was to compare in vitro variables of PCs produced by apheresis (AP-PC) or the buffy coat (BC-PC) method by applying a number of new and established assays. STUDY DESIGN AND METHODS: Standard TRIMA Accel (Gambro BCT) AP-PCs (n = 20) and BC-PCs (n = 20) were stored in 100 percent plasma and changes in mitochondrial membrane ...

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Authors: Albanyan, A; Harrison, P; Murphy, M

• Publication status: Published
• Journal: Transfusion
• Volume: 49
• Issue: 1
• Pages: 108-117
• Publication date: 2009-01-01
• DOI: 10.1111/j.1537-2995.2008.01942.x
• EISSN: 1537-2995
• ISSN: 0041-1132
• Language: English
• Keywords: Plateletpheresis; Preservation, Biological; Blood Platelets; Humans; Apoptosis; Cell Survival; Antigens, CD; Platelet Activation; Membrane Potential, Mitochondrial; Time Factors