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Journal article

Structural insights into the mode of action of a pure antiestrogen.

Abstract:

BACKGROUND: Estrogens exert their effects on target tissues by binding to a nuclear transcription factor termed the estrogen receptor (ER). Previous structural studies have demonstrated that each class of ER ligand (agonist, partial agonist, and SERM antagonist) induces distinctive orientations in the receptor's carboxy-terminal transactivation helix. The conformation of this portion of the receptor determines whether ER can recruit and interact with the components of the transcriptional mach...

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Publication status:
Published

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Journal:
Structure (London, England : 1993) More from this journal
Volume:
9
Issue:
2
Pages:
145-153
Publication date:
2001-02-01
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Language:
English
Keywords:
Pubs id:
pubs:317561
UUID:
uuid:0bf3fbb3-9289-4925-a052-caa923020a5e
Local pid:
pubs:317561
Source identifiers:
317561
Deposit date:
2012-12-19

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