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Impaired mesial frontal and putamen activation in Parkinson's disease: a positron emission tomography study.

Abstract:

Selection of movement in normal subjects has been shown to involve the premotor, supplementary motor, anterior cingulate, posterior parietal, and dorsolateral prefrontal areas. In Parkinson's disease (PD), the primary pathological change is degeneration of the nigrostriatal dopaminergic projections, and this is associated with difficulty in initiating actions. We wished to investigate the effect of the nigral abnormality in PD on cortical activation during movement. Using C15O2 and positron e...

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Publication status:
Published

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Publisher copy:
10.1002/ana.410320206

Authors


Playford, ED More by this author
Jenkins, IH More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Frackowiak, RS More by this author
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Journal:
Annals of neurology
Volume:
32
Issue:
2
Pages:
151-161
Publication date:
1992-08-05
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
URN:
uuid:0befbc95-ba3f-451e-b267-aee651d050d9
Source identifiers:
16775
Local pid:
pubs:16775

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