Pindolol occupancy of 5-HT(1A) receptors measured in vivo using small animal positron emission tomography with carbon-11 labeled WAY 100635.

Journal article

Positron emission tomography (PET), following an intravenous injection of [carbonyl-(11)C]WAY 100635, was used to image central 5-HT(1A) receptors in rat following pretreatment with graded doses of (-)-pindolol (0.001-3 mg/kg, i.v.). The use of PET had advantages over ex vivo radioligand binding methods in that it produced parametric image volumes and reduced errors due to inter-rat variability. Time-radioactivity curves from regions of interest (ROI) acquired from individual rats enabled the...

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Authors: Hirani, E; Opacka-Juffry, J; Gunn, R; Khan, I; Sharp, T

• Publication status: Published
• Journal: Synapse (New York, N.Y.)
• Volume: 36
• Issue: 4
• Pages: 330-341
• Publication date: 2000-06-01
• DOI: 10.1002/(sici)1098-2396(20000615)36:4<330::aid-syn10>3.3.co;2-8
• EISSN: 1098-2396
• ISSN: 0887-4476
• Language: English
• Keywords: Brain; Rats, Sprague-Dawley; Carbon Radioisotopes; Rats; Receptors, Serotonin; Animals; Male; Piperazines; Dose-Response Relationship, Drug; Receptors, Serotonin, 5-HT1; Tomography, Emission-Computed; Pyridines; Serotonin Antagonists; Pindolol