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Remote ischemic preconditioning impairs ventricular function and increases infarct size after prolonged ischemia in the isolated neonatal rabbit heart

Abstract:

Objectives: Remote ischemic preconditioning (rIPC) reduces myocardial injury in adults and children undergoing cardiac surgery. We compared the effect of rIPC in adult and neonatal rabbits to investigate whether protection against ischemia-reperfusion injury can be achieved in the newborn heart by (1) in vivo rIPC and (2) dialysate from adult rabbits undergoing rIPC. Methods: Isolated hearts from newborn and adult rabbits were randomized into 3 subgroups (control, in vivo rIPC, and dialysate ...

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Publisher copy:
10.1016/j.jtcvs.2013.05.022

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Journal:
Journal of Thoracic and Cardiovascular Surgery More from this journal
Volume:
147
Issue:
3
Pages:
1049-1055
Publication date:
2014-03-01
DOI:
EISSN:
1097-685X
ISSN:
0022-5223
Language:
English
Pubs id:
pubs:452590
UUID:
uuid:0bec9bd4-b63d-4c76-884d-b53efb30d990
Local pid:
pubs:452590
Source identifiers:
452590
Deposit date:
2014-05-20

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