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Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization.

Abstract:

MicroRNAs are short, endogenous RNAs that direct posttranscriptional regulation of gene expression vital for many developmental and cellular functions. Implicated in the pathogenesis of several human diseases, this group of RNAs provides interesting targets for therapeutic intervention. Anti-microRNA oligonucleotides constitute a class of synthetic antisense oligonucleotides used to interfere with microRNAs. In this study, we investigate the effects of chemical modifications and truncations o...

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Publisher copy:
10.5402/2012/407154

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Journal:
ISRN pharmaceutics
Volume:
2012
Pages:
407154
Publication date:
2012-01-01
DOI:
EISSN:
2090-6153
ISSN:
2090-6145
URN:
uuid:0be8186e-46ae-41ff-b39e-29765433f39e
Source identifiers:
322993
Local pid:
pubs:322993
Language:
English

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