- Abstract:
-
ATP-sensitive K-channels in the cloned beta-cell line HIT T15 were studied by patch-clamp methods; by measurement of 86Rb efflux; and by [3H]glibenclamide binding to isolated membrane preparations. In inside-out patches a 50 pS K-channel was found which was blocked by ATP or tolbutamide applied to the intracellular membrane surface. A minimum estimate of about 500 channels per beta-cell was obtained by combining whole-cell and single-channel data. The rate of efflux of 86Rb from 86RbCl-loaded...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/bf00373140
-
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- Publisher:
- Springer-Verlag
- Journal:
- Pflugers Archiv : European journal of physiology
- Volume:
- 415
- Issue:
- 1
- Pages:
- 47-55
- Publication date:
- 1989-10-05
- DOI:
- EISSN:
-
1432-2013
- ISSN:
-
0031-6768
- URN:
-
uuid:0be2ff29-d959-4f5f-aacf-6d43e32e4fcd
- Source identifiers:
-
113910
- Local pid:
- pubs:113910
- Copyright date:
- 1989
Journal article
ATP-sensitive K-channels in HIT T15 beta-cells studied by patch-clamp methods, 86Rb efflux and glibenclamide binding.
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