Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions.

Journal article

A metabolically protected analog of substance P, [pGlu5-MePhe8-MeGly9]SP(5-11) (DiMe-C7), was approximately equipotent with substance P in causing increased locomotor activity after microinfusion into the ventral tegmental area of rat brain, but the effects of DiMe-C7 on behavior were considerably prolonged. There was little metabolic degradation of tritiated DiMe-C7 for up to 1 hour after infusion, whereas tritiated substance P was completely degraded within 10 minutes.

Authors: Eison, A; Iversen, S; Sandberg, B; Watson, S; Hanley, MR

• Publication status: Published
• Journal: Science (New York, N.Y.)
• Volume: 215
• Issue: 4529
• Pages: 188-190
• Publication date: 1982-01-01
• DOI: 10.1126/science.6171884
• EISSN: 1095-9203
• ISSN: 0036-8075
• Language: English
• Keywords: Pyrrolidonecarboxylic Acid; Peptide Fragments; Substance P; Animals; Behavior, Animal; Motor Activity; Brain; Rats