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Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions.

Abstract:
A metabolically protected analog of substance P, [pGlu5-MePhe8-MeGly9]SP(5-11) (DiMe-C7), was approximately equipotent with substance P in causing increased locomotor activity after microinfusion into the ventral tegmental area of rat brain, but the effects of DiMe-C7 on behavior were considerably prolonged. There was little metabolic degradation of tritiated DiMe-C7 for up to 1 hour after infusion, whereas tritiated substance P was completely degraded within 10 minutes.
Publication status:
Published

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Publisher copy:
10.1126/science.6171884

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
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Journal:
Science (New York, N.Y.)
Volume:
215
Issue:
4529
Pages:
188-190
Publication date:
1982-01-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:0bd9527e-ac57-4d94-95cc-e2025a4d79d8
Source identifiers:
13151
Local pid:
pubs:13151

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