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Determinants of structure-function relationships among bisphosphonates

Abstract:

Bisphosphonates are a chemical class of compounds in widespread use since the 1970s for the management of disorders of bone metabolism, such as Paget's disease and osteoporosis. The members of this drug class share a common P-C-P backbone structure, where C is carbon and each P is a phosphonate group; the 2 phosphonate groups act as a "bone hook" and are essential for binding to hydroxyapatite. Individual bisphosphonates exhibit differential binding to hydroxyapatite and exert differential ac...

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Publication status:
Published

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Publisher copy:
10.1016/j.bone.2007.03.002

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Volume:
40
Issue:
5
Pages:
S21-S25
Publication date:
2007-05-05
DOI:
ISSN:
8756-3282
URN:
uuid:0bd5a0b2-ca98-4989-8972-2974705341bf
Source identifiers:
109131
Local pid:
pubs:109131

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