Journal article icon

Journal article

Down-regulation of Th1-mediated pathology in experimental arthritis by stimulation of the Th2 arm of the immune response.

Abstract:

OBJECTIVE: To assess whether systemic administration of recombinant interferon-gamma (rIFN gamma), a proinflammatory cytokine that influences the differentiation of naive T cells into Th1 cells, promotes the induction of arthritis in DBA/1 mice immunized with type II collagen (CII) in Freund's incomplete adjuvant (IFA) and to determine the antiarthritic effect of treatment with CII in IFA. METHODS: DBA/1 mice were immunized with CII in IFA and injected intraperitoneally with rIFN gamma (8,00...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/art.10832

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Arthritis and rheumatism More from this journal
Volume:
48
Issue:
3
Pages:
839-845
Publication date:
2003-03-01
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
Language:
English
Keywords:
Pubs id:
pubs:224282
UUID:
uuid:0bd507fe-c4ad-4ce2-9eb5-542c6ba1a732
Local pid:
pubs:224282
Source identifiers:
224282
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP