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From genome-wide association studies to rational drug target prioritisation in inflammatory arthritis

Abstract:

Early identification of genetically validated drug targets can increase the chances of successful late-stage drug development. 81 high-quality genome-wide association studies (GWAS) in diseases related to inflammatory arthritis have been curated into the GWAS catalogue; however, translation of genetic findings from GWAS into rational drug target discovery has been poor. No human genetic findings have completely driven drug development for inflammatory arthritis; however, genetic associations ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Wellcome Trust Centre for Human Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Oxford college:
Worcester College
Role:
Author
ORCID:
0000-0003-1503-6017
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Wellcome Trust Centre for Human Genetics
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Lancet Rheumatology Journal website
Volume:
2
Issue:
1
Pages:
e50-e62
Publication date:
2019-10-12
Acceptance date:
2019-10-12
DOI:
ISSN:
2665-9913
Source identifiers:
1080764
Language:
English
Keywords:
Pubs id:
pubs:1080764
UUID:
uuid:0bcf38a2-994f-4507-93ab-02d33f0e6d55
Local pid:
pubs:1080764
Deposit date:
2020-01-03

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