- Abstract:
-
Recommended initial treatment of severe chloroquine-resistant falciparum malaria consists of a 4-h loading infusion of 20 mg of quinine dihydrochloride (salt)/kg of body weight. To achieve and maintain therapeutic blood quinine concentrations (10 mg/l) safely and rapidly, a consecutive-infusion regimen (7 mg of salt/kg of body weight over 30 min followed by 10 mg of salt/kg of body weight over 4 h) based on pharmacokinetic parameters in cerebral malaria has been suggested. This regimen was ev...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/infdis/161.6.1305
-
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- Journal:
- The Journal of infectious diseases
- Volume:
- 161
- Issue:
- 6
- Pages:
- 1305-1308
- Publication date:
- 1990-06-05
- DOI:
- EISSN:
-
1537-6613
- ISSN:
-
0022-1899
- URN:
-
uuid:0bc58492-a9e1-4ecb-84e4-cd4c7c814861
- Source identifiers:
-
43383
- Local pid:
- pubs:43383
- Language:
- English
- Keywords:
- Copyright date:
- 1990
Journal article
A safe and effective consecutive-infusion regimen for rapid quinine loading in severe falciparum malaria.
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