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Journal article

A safe and effective consecutive-infusion regimen for rapid quinine loading in severe falciparum malaria.

Abstract:

Recommended initial treatment of severe chloroquine-resistant falciparum malaria consists of a 4-h loading infusion of 20 mg of quinine dihydrochloride (salt)/kg of body weight. To achieve and maintain therapeutic blood quinine concentrations (10 mg/l) safely and rapidly, a consecutive-infusion regimen (7 mg of salt/kg of body weight over 30 min followed by 10 mg of salt/kg of body weight over 4 h) based on pharmacokinetic parameters in cerebral malaria has been suggested. This regimen was ev...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/161.6.1305

Authors


Supanaranond, W More by this author
Pukrittayakamee, S More by this author
Karbwang, J More by this author
Molunto, P More by this author
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Journal:
The Journal of infectious diseases
Volume:
161
Issue:
6
Pages:
1305-1308
Publication date:
1990-06-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:0bc58492-a9e1-4ecb-84e4-cd4c7c814861
Source identifiers:
43383
Local pid:
pubs:43383

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