Mid-follicular phase pulses of inhibin B are absent in polycystic ovarian syndrome and are initiated by successful laparoscopic ovarian diathermy: a possible mechanism regulating emergence of the dominant follicle.

Journal article

The hypothalamic pulse generator of GnRH is recognized to be central to ovulatory function as evidenced by the anovulation of women with hypogonadotrophic hypogonadism due to Kallmann's syndrome or severe anorexia nervosa. LH is released from the anterior pituitary in pulses, the frequency of which is closely entrained with those of GnRH. In contrast, secretion of FSH is influenced by a number of regulatory molecules, including GnRH, estradiol, inhibin, and activin. The close temporal relatio...

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Authors: Lockwood, G; Muttukrishna, S; Groome, N; Matthews, DR; Ledger, W

• Publication status: Published
• Journal: Journal of clinical endocrinology and metabolism
• Volume: 83
• Issue: 5
• Pages: 1730-1735
• Publication date: 1998-05-01
• DOI: 10.1210/jc.83.5.1730
• EISSN: 1945-7197
• ISSN: 0021-972X
• Language: English
• Keywords: Ovary; Periodicity; Luteinizing Hormone; Female; Ovarian Follicle; Diathermy; Polycystic Ovary Syndrome; Follicle Stimulating Hormone; Laparoscopy; Fourier Analysis; Follicular Phase; Humans; Inhibins