- Abstract:
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BACKGROUND: The human malaria parasite Plasmodium falciparum exploits antigenic diversity and within-host antigenic variation to evade the host's immune system. Of particular importance are the highly polymorphic var genes that encode the family of cell surface antigens PfEMP1 (Plasmodium falciparum Erythrocyte Membrane Protein 1). It has recently been shown that in spite of their extreme diversity, however, these genes fall into distinct groups according to chromosomal location or sequence ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 469.1KB)
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- Publisher copy:
- 10.1186/1475-2875-7-18
-
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- Publisher:
- BioMed Central Ltd. Publisher's website
- Journal:
- Malaria Journal Journal website
- Volume:
- 7
- Issue:
- 1
- Pages:
- Article: 18
- Publication date:
- 2008-01-01
- DOI:
- EISSN:
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1475-2875
- ISSN:
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1475-2875
- URN:
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uuid:0bbf6a33-8a17-4f68-ab9f-3fd12546a50c
- Source identifiers:
-
209420
- Local pid:
- pubs:209420
- Copyright holder:
- Recker et al.
- Copyright date:
- 2008
- Notes:
- © 2008 Recker et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal article
The effects of a partitioned var gene repertoire of Plasmodium falciparum on antigenic diversity and the acquisition of clinical immunity.
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Wellcome Trust
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James Martin 21st Century School, Oxford
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