Journal article icon

Journal article

Structure of dystrophia myotonica protein kinase.

Abstract:

Dystrophia myotonica protein kinase (DMPK) is a serine/threonine kinase composed of a kinase domain and a coiled-coil domain involved in the multimerization. The crystal structure of the kinase domain of DMPK bound to the inhibitor bisindolylmaleimide VIII (BIM-8) revealed a dimeric enzyme associated by a conserved dimerization domain. The affinity of dimerisation suggested that the kinase domain alone is insufficient for dimerisation in vivo and that the coiled-coil domains are required for ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/pro.82

Authors


Elkins, JM More by this author
Niesen, FH More by this author
Fedorov, O More by this author
Expand authors...
Journal:
Protein science : a publication of the Protein Society
Volume:
18
Issue:
4
Pages:
782-791
Publication date:
2009-04-05
DOI:
EISSN:
1469-896X
ISSN:
0961-8368
URN:
uuid:0bbe8deb-0618-4a80-ac0b-a140308d983a
Source identifiers:
34655
Local pid:
pubs:34655

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP