- Abstract:
-
Dystrophia myotonica protein kinase (DMPK) is a serine/threonine kinase composed of a kinase domain and a coiled-coil domain involved in the multimerization. The crystal structure of the kinase domain of DMPK bound to the inhibitor bisindolylmaleimide VIII (BIM-8) revealed a dimeric enzyme associated by a conserved dimerization domain. The affinity of dimerisation suggested that the kinase domain alone is insufficient for dimerisation in vivo and that the coiled-coil domains are required for ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/pro.82
-
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- Journal:
- Protein science : a publication of the Protein Society
- Volume:
- 18
- Issue:
- 4
- Pages:
- 782-791
- Publication date:
- 2009-04-05
- DOI:
- EISSN:
-
1469-896X
- ISSN:
-
0961-8368
- URN:
-
uuid:0bbe8deb-0618-4a80-ac0b-a140308d983a
- Source identifiers:
-
34655
- Local pid:
- pubs:34655
- Copyright date:
- 2009
Journal article
Structure of dystrophia myotonica protein kinase.
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