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Structure-function relationships of the extracellular domain of the autosomal dominant polycystic kidney disease-associated protein, polycystin-1.

Abstract:

Polycystin-1 (PC-1) is a member of a novel family of proteins that have a multidomain structure. Although the C-terminal intracellular segments have been extensively studied, mainly with respect to their putative involvement in cell signalling, the potential function of the extracellular domains has received less attention. Mutations in PC-1 result in autosomal dominant polycystic kidney disease (ADPKD) which is characterised by perturbation of transport resulting in fluid accumulation, cell ...

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Authors


Weston, BS More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
FEBS letters
Volume:
538
Issue:
1-3
Pages:
8-13
Publication date:
2003-03-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:0bbd15bd-144a-425c-a62b-21f58d334e81
Source identifiers:
55794
Local pid:
pubs:55794

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