Journal article
A lipid bound actin meshwork organizes liquid phase separation in model membranes
- Abstract:
-
The eukaryotic cell membrane is connected to a dense actin rich cortex. We present FCS and STED experiments showing that dense membrane bound actin networks have severe influence on lipid phase separation. A minimal actin cortex was bound to a supported lipid bilayer via biotinylated lipid streptavidin complexes (pinning sites). In general, actin binding to ternary membranes prevented macroscopic liquid-ordered and liquid-disordered domain formation, even at low temperature. Instead, dependin...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife Journal website
- Volume:
- 2014
- Issue:
- 3
- Article number:
- e01671
- Publication date:
- 2014-03-18
- Acceptance date:
- 2014-02-14
- DOI:
- EISSN:
-
2050-084X
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:0bb429a8-ca99-4b62-b8a8-320dbed2ae42
- Local pid:
- pubs:450621
- Source identifiers:
-
450621
- Deposit date:
- 2014-08-06
Terms of use
- Copyright holder:
- Honigmann et al
- Copyright date:
- 2014
- Notes:
- © 2014, Honigmann et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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