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Electron transfer and catalytic control by the iron-sulfur clusters in a respiratory enzyme, E. coli fumarate reductase.

Abstract:

Factors governing the efficacy of long-range electron relays in enzymes have been examined using protein film voltammetry in conjunction with site-directed mutagenesis. Investigations of the fumarate reductase from Escherichia coli, in which three Fe-S clusters relay electrons over more than 30 A, lead to the conclusion that varying the medial [4Fe-4S] cluster potential over a 100 mV range does not have a significant effect on the inherent kinetics of electron transfer to and from the active-...

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Publication status:
Published

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Publisher copy:
10.1021/ja043404q

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Journal:
Journal of the American Chemical Society
Volume:
127
Issue:
19
Pages:
6977-6989
Publication date:
2005-05-01
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Source identifiers:
33093

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