Journal article icon

Journal article

Human monoclonal antibodies to HIV-1 gp140 from mice bearing YAC-based human immunoglobulin transloci.

Abstract:

Mice carrying human immunoglobulin transloci were immunised with HIV-1 gp140 antigen to gain insight into the range and nature of human monoclonal antibodies (mAbs) that can be elicited from such humanised mice. Using five-feature mice that harbour YAC-based germline-configuration human IgM, Igκ and Igλ transloci in a mouse background disrupted for endogenous mouse IgH and Igκ expression, gp140-specific human IgM mAbs were readily elicited following serial immunisation. These mAbs were conver...

Expand abstract

Actions


Access Document


Publisher copy:
10.1093/protein/gzr038

Authors


Expand authors...
Journal:
Protein engineering, design and selection : PEDS
Volume:
24
Issue:
10
Pages:
791-799
Publication date:
2011-10-05
DOI:
EISSN:
1741-0134
ISSN:
1741-0126
URN:
uuid:0ba99962-8b9f-47ce-94aa-3843dda9f32f
Source identifiers:
167586
Local pid:
pubs:167586

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP