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Dimerization of lithiated terminal aziridines.

Abstract:
Let's get together: Dimerization of enantiopure terminal aziridines by lithiation gives efficiently N-protected 2-ene-1,4-diamines with complete selectivity for the E olefin (see scheme). The usefulness of the method was demonstrated in a concise synthesis of (R,S,S,R)-2,5-diamino-1,6-diphenylhexane- 3,4-diol, the core unit of many extremely potent HIV protease inhibitors and also asymmetric catalysts. (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH and Co. KGaA.
Publication status:
Published

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Publisher copy:
10.1002/anie.200503303

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Angewandte Chemie (International ed. in English) More from this journal
Volume:
45
Issue:
6
Pages:
935-938
Publication date:
2006-01-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Language:
English
Keywords:
Pubs id:
pubs:33343
UUID:
uuid:0ba5e0b7-dc88-4186-ab52-60e2eeef3687
Local pid:
pubs:33343
Source identifiers:
33343
Deposit date:
2012-12-19

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