Journal article
Coordinated hedgehog signaling induces new hair follicles in adult skin
- Abstract:
-
Hair follicle (HF) development is orchestrated by coordinated signals from adjacent epithelial and mesenchymal cells. In humans this process only occurs during embryogenesis and viable strategies to induce new HFs in adult skin are lacking. Here, we reveal that activation of Hedgehog (Hh) signaling in adjacent epithelial and stromal cells induces new HFs in adult, unwounded dorsal mouse skin. Formation of de novo HFs recapitulated embryonic HF development, and mature follicles produced hair c...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Bibliographic Details
- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife Journal website
- Volume:
- 9
- Article number:
- e46756
- Publication date:
- 2020-03-17
- Acceptance date:
- 2020-02-07
- DOI:
- EISSN:
-
2050-084X
- ISSN:
-
2050-084X
- Pmid:
-
32178760
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1096014
- Local pid:
- pubs:1096014
- Deposit date:
- 2020-04-23
Terms of use
- Copyright holder:
- Sun et al.
- Copyright date:
- 2020
- Rights statement:
- © Copyright Sun et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record