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Critical role for the Val/Gly86 HLA-DR beta dimorphism in autoantigen presentation to human T cells.

Abstract:

Helper T lymphocytes recognize fragments of foreign (or self) antigens in the peptide-binding clefts of major histocompatibility complex class II molecules; their activation is a crucial step in the induction of many immune and autoimmune responses. While studying the latter, we raised a T-cell line from the thymus of a myasthenia gravis patient against recombinant alpha subunit of the human acetylcholine receptor, the target of this autoimmune disease. The line responds to the 144-156 region...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.88.16.7343

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
88
Issue:
16
Pages:
7343-7347
Publication date:
1991-08-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:108315
UUID:
uuid:0b9c56ea-9b0b-4f61-9fdc-e9b8b4819850
Local pid:
pubs:108315
Source identifiers:
108315
Deposit date:
2013-11-17

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