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Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer.

Abstract:

Studies of regulation of the haematopoietic growth factor erythropoietin led to the unexpected discovery of a widespread system of direct oxygen sensing that regulates gene expression in animals. The oxygen-sensitive signal is generated by a series of non-haem Fe(II)- and 2-oxoglutarate-dependent dioxygenases that catalyse the post-translational hydroxylation of specific residues in the transcription factor hypoxia-inducible factor (HIF). These hydroxylations promote both oxygen-dependent deg...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
Journal:
Journal of physiology More from this journal
Volume:
591
Issue:
Pt 8
Pages:
2027-2042
Publication date:
2013-04-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Language:
English
Keywords:
Pubs id:
pubs:384104
UUID:
uuid:0b98c0d9-0d33-46d1-91f5-d890ad97c42c
Local pid:
pubs:384104
Source identifiers:
384104
Deposit date:
2013-11-17

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