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Journal article

Syndromic obesity and diabetes: changes in body composition with age and mutation analysis of ALMS1 in 12 United Kingdom kindreds with Alstrom syndrome.

Abstract:

CONTEXT: Alström syndrome (AS) is a monogenic form of infancy-onset obesity and insulin resistance, caused by ALMS1 mutations. The natural history of the insulin resistance is unknown, in particular how this relates to changes in body composition. It is also unclear how ALMS1 mutations relate to the characteristic phenotype. OBJECTIVES: Our objectives were to characterize body composition and metabolic parameters, to establish ALMS1 mutation spectrum of United Kingdom AS patients, and to dete...

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Publication status:
Published

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Publisher copy:
10.1210/jc.2005-2633

Authors


Minton, JA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Ricketts, CJ More by this author
Crabtree, N More by this author
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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
91
Issue:
8
Pages:
3110-3116
Publication date:
2006-08-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:0b946c5b-b91a-4f73-9516-3d14e2d2f2c3
Source identifiers:
29521
Local pid:
pubs:29521

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