Effect of age and glycaemic control on the association between fibrinogen and risk of acute coronary events after transient ischaemic attack or stroke.

Journal article

BACKGROUND: Fibrinogen is an independent risk factor for acute vascular events, but there is uncertainty as to whether it is causal. One potential causal mechanism is the formation of low permeability fibrin clot in association with raised fibrinogen. We hypothesised that if this effect of fibrinogen were causally related to risk of vascular events, the risk relationship would be affected by the two other factors that affect fibrin clot permeability - age and glycaemic control. METHODS: We s...

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Authors: Howard, S; Algra, A; Rothwell, P

• Publication status: Published
• Journal: Cerebrovascular diseases (Basel, Switzerland)
• Volume: 25
• Issue: 1-2
• Pages: 136-143
• Publication date: 2008-01-01
• DOI: 10.1159/000112324
• EISSN: 1421-9786
• ISSN: 1015-9770
• Language: English
• Keywords: Blood Glucose; Male; Aged; Female; Death, Sudden, Cardiac; Predictive Value of Tests; Stroke; Middle Aged; Cohort Studies; Myocardial Infarction; Age Factors; Risk Factors; Fibrinogen; Cerebrovascular Cohort Studies Collaboration; Humans; Ischemic Attack, Transient