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Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia.

Abstract:

Epigenetic therapies, including DNA methyltransferase and histone deacetylase inhibitors, represent important new treatment modalities in hematologic malignancies, but their mechanism of action remains unknown. We reasoned that up-regulation of epigenetically silenced tumor antigens may induce an immunologically mediated antitumor response and contribute to their clinical activity. In this study, we demonstrate that azacitidine (AZA) and sodium valproate (VPA) up-regulate expression of melano...

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Publication status:
Published

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Journal:
Blood
Volume:
116
Issue:
11
Pages:
1908-1918
Publication date:
2010-09-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
90344

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