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Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases.

Abstract:

Protein kinases are involved in many essential cellular processes and their deregulation can lead to a variety of diseases, including cancer. The pharmaceutical industry has invested heavily in the identification of kinase inhibitors to modulate these disease-promoting pathways, resulting in several successful drugs. However, the field is challenging as it is difficult to identify novel selective inhibitors with good pharmacokinetic/pharmacodynamic properties. In addition, resistance to kinas...

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Publication status:
Published

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Publisher copy:
10.4155/fmc.13.216

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
Publisher:
Future Science
Journal:
Future medicinal chemistry More from this journal
Volume:
6
Issue:
5
Pages:
541-561
Publication date:
2014-04-01
DOI:
EISSN:
1756-8927
ISSN:
1756-8919
Language:
English
Keywords:
Pubs id:
pubs:462210
UUID:
uuid:0b7ace66-6e5c-4b4e-b8c4-d069c308eb2c
Local pid:
pubs:462210
Source identifiers:
462210
Deposit date:
2014-05-18

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