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Cp2ZrMeCl: A reagent for asymmetric methyl addition.

Abstract:

The use of Cp2ZrMeCl is described as a source of nucleophilic methyl in asymmetric catalysis. This easily prepared reagent is bench stable, weighable in air, and generally useful in highly enantioselective copper-catalyzed addition reactions at room temperature. Methyl is successfully (generally > 90% ee) added in 1,4-additions to cyclic and acyclic α,β-unsaturated ketones, to provide tertiary and quaternary centers. Examples of catalyst controlled diastereoselective 1,6-addition and dynam...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.orglett.6b01829

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More from this funder
Name:
European Research Council
Grant:
Consolidator grant (autocat
More from this funder
Name:
Engineering and Physical Sciences Research Council
Grant:
CentreforDoctoralTraininginSynthesisforBiology
Medi-cine(EP/L015838/1)
EP/M002144/1
EP/M025241/1
EP/N022246/1
Publisher:
American Chemical Society
Journal:
Organic Letters More from this journal
Volume:
18
Issue:
15
Pages:
3814–3817
Publication date:
2016-07-26
Acceptance date:
2016-07-18
DOI:
EISSN:
1523-7052
ISSN:
1523-7060
Pubs id:
pubs:635394
UUID:
uuid:0b7156d3-a554-4be6-b168-84ebfc47d942
Local pid:
pubs:635394
Source identifiers:
635394
Deposit date:
2016-07-26

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