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The DNA translocase activity of FANCM protects stalled replication forks.

Abstract:

FANCM is the most highly conserved protein within the Fanconi anaemia (FA) tumour suppressor pathway. However, although FANCM contains a helicase domain with translocase activity, this is not required for its role in activating the FA pathway. Instead, we show here that FANCM translocaseactivity is essential for promoting replication fork stability. We demonstrate that cells expressing translocase-defective FANCM show altered global replication dynamics due to increased accumulation of stalle...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/dds013

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Journal:
Human molecular genetics More from this journal
Volume:
21
Issue:
9
Pages:
2005-2016
Publication date:
2012-05-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906

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