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Neural stem cell transplantation benefits a monogenic neurometabolic disorder during the symptomatic phase of disease.

Abstract:

Although we and others have demonstrated that neural stem cells (NSCs) may impact such neurogenetic conditions as lysosomal storage diseases when transplanted at birth, it has remained unclear whether such interventions can impact well-established mid-stage disease, a situation often encountered clinically. Here we report that when NSCs were injected intracranially into the brain of adult symptomatic Sandhoff (Hexb(-/-)) mice, cells migrated far from the injection site and integrated into the...

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Publication status:
Published

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Publisher copy:
10.1002/stem.163

Authors


Jeyakumar, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Stuckey, DJ More by this author
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Journal:
Stem cells (Dayton, Ohio)
Volume:
27
Issue:
9
Pages:
2362-2370
Publication date:
2009-09-05
DOI:
EISSN:
1549-4918
ISSN:
1066-5099
URN:
uuid:0b6a5dd1-ee19-4020-92e6-01730f89a82f
Source identifiers:
130934
Local pid:
pubs:130934

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