Journal article
Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats.
- Abstract:
- Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.
- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.brainres.2008.05.019
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Authors
Bibliographic Details
- Journal:
- Brain research
- Volume:
- 1221
- Pages:
- 93-97
- Publication date:
- 2008-07-01
- DOI:
- EISSN:
-
1872-6240
- ISSN:
-
0006-8993
- Source identifiers:
-
185207
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:185207
- UUID:
-
uuid:0b67eb6b-64e8-4ca5-84ae-e1760ae1d8f0
- Local pid:
- pubs:185207
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2008
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