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Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats.

Abstract:
Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.
Publication status:
Published

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Journal:
Brain research
Volume:
1221
Pages:
93-97
Publication date:
2008-07-01
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
Source identifiers:
185207
Language:
English
Keywords:
Pubs id:
pubs:185207
UUID:
uuid:0b67eb6b-64e8-4ca5-84ae-e1760ae1d8f0
Local pid:
pubs:185207
Deposit date:
2012-12-19

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