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Important messages in the 'post': recent discoveries in 5-HT neurone feedback control.

Abstract:

The neurotransmitter 5-hydroxytryptamine (5-HT, serotonin) mediates important brain functions and contributes to the pathophysiology and successful drug treatment of many common psychiatric disorders, especially depression. It is established that a key mechanism involved in the control of 5-HT neurones is feedback inhibition by presynaptic 5-HT autoreceptors, which are located on 5-HT cell bodies and nerve terminals. However, recent experiments have discovered an unexpected complexity of 5-HT...

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Publication status:
Published

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Publisher copy:
10.1016/j.tips.2007.10.009

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Boothman, L More by this author
Quérée, P More by this author
Journal:
Trends in pharmacological sciences
Volume:
28
Issue:
12
Pages:
629-636
Publication date:
2007-12-05
DOI:
EISSN:
1873-3735
ISSN:
0165-6147
URN:
uuid:0b675aca-688a-4a3b-9439-0c7628b717ff
Source identifiers:
185291
Local pid:
pubs:185291

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