- Abstract:
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BACKGROUND: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), an inflammatory enzyme expressed in atherosclerotic plaques, is a therapeutic target being assessed in trials of vascular disease prevention. We investigated associations of circulating Lp-PLA(2) mass and activity with risk of coronary heart disease, stroke, and mortality under different circumstances. METHODS: With use of individual records from 79 036 participants in 32 prospective studies (yielding 17 722 incident fatal or ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0140-6736(10)60319-4
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- Journal:
- Lancet
- Volume:
- 375
- Issue:
- 9725
- Pages:
- 1536-1544
- Publication date:
- 2010-05-05
- DOI:
- EISSN:
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1474-547X
- ISSN:
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0140-6736
- URN:
-
uuid:0b666286-05d3-490c-9d46-4b64d51f3b48
- Source identifiers:
-
92402
- Local pid:
- pubs:92402
- Copyright date:
- 2010
Journal article
Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies.
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