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Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer

Abstract:

Colorectal cancer is initiated in colonic crypts. A succession of genetic mutations or epigenetic changes can lead to homeostasis in the crypt being overcome, and subsequent unbounded growth. We consider the dynamics of a single colorectal crypt by using a compartmental approach [Tomlinson IPM, Bodmer WF (1995) Proc Natl Acad Sci USA 92: 11130-11134], which accounts for populations of stem cells, differential cells, and transit cells. That original model made the simplifying assumptions th...

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M. D. Johnston More by this author
C. M. Edwards More by this author
W. F. Bodmer More by this author
P. K. Maini More by this author
S. J. Chapman More by this author
Publication date:
2007
URN:
uuid:0b6465b1-06d9-44a4-83df-8ee0b4fe0cba
Local pid:
oai:eprints.maths.ox.ac.uk:574

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