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Safety of recombinant fowlpox strain FP9 and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers.

Abstract:

The ability to generate potent antigen-specific T cell responses by vaccination has been a major hurdle in vaccinology. Vaccinia virus and avipox viruses have been shown to be capable of expressing antigens in mammalian cells and can induce a protective immune response against several mammalian pathogens. We report on two such vaccine constructs, modified vaccinia virus Ankara and FP9 (an attenuated fowlpox virus) both expressing the pre-erythrocytic malaria antigen thrombospondin-related adh...

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Publication status:
Published

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Journal:
Vaccine More from this journal
Volume:
24
Issue:
15
Pages:
3026-3034
Publication date:
2006-04-01
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
Language:
English
Keywords:
Pubs id:
pubs:33398
UUID:
uuid:0b633c5b-004f-4846-814f-d717da56e5e4
Local pid:
pubs:33398
Source identifiers:
33398
Deposit date:
2012-12-19

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