Journal article
Long-term evolution of antibiotic tolerance in Pseudomonas aeruginosa lung infections
- Abstract:
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Pathogenic bacteria respond to antibiotic pressure with the evolution of resistance but survival can also depend on their ability to tolerate antibiotic treatment, known as tolerance. While a variety of resistance mechanisms and underlying genetics are well characterized in vitro and in vivo, an understanding of the evolution of tolerance, and how it interacts with resistance in situ is lacking. We assayed for tolerance and resistance in isolates of Pseudomonas aeruginosa from chronic cystic fibrosis lung infections spanning up to 40 years of evolution, with 3 clinically relevant antibiotics: meropenem, ciprofloxacin, and tobramycin. We present evidence that tolerance is under positive selection in the lung and that it can act as an evolutionary stepping stone to resistance. However, by examining evolutionary patterns across multiple patients in different clone types, a key result is that the potential for an association between the evolution of resistance and tolerance is not inevitable, and difficult to predict.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 817.8KB, Terms of use)
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- Publisher copy:
- 10.1093/evlett/qrad034
Authors
- Publisher:
- Oxford University Press
- Journal:
- Evolution Letters More from this journal
- Volume:
- 7
- Issue:
- 6
- Pages:
- 389-400
- Publication date:
- 2023-09-20
- Acceptance date:
- 2023-08-02
- DOI:
- EISSN:
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2056-3744
- Pmid:
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38045720
- Language:
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English
- Keywords:
- Pubs id:
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1547273
- Local pid:
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pubs:1547273
- Deposit date:
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2023-12-11
Terms of use
- Copyright holder:
- Ghoul et al.
- Copyright date:
- 2023
- Rights statement:
- © The Author(s) 2023. Published by Oxford University Press on behalf of The Society for the Study of Evolution (SSE) and European Society for Evolutionary Biology (ESEN). This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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