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Association between both lipid and protein oxidation and the risk of fatal or non-fatal coronary heart disease in a human population.

Abstract:

The role of oxidative damage in the aetiology of coronary disease remains controversial, as clinical trials investigating the effect of antioxidants have not generally been positive. In the present study, 227 coronary cases, identified from a cohort study, were matched, by age and gender, with 420 controls in a nested case-control design. Stored plasma samples were analysed for F2-isoprostanes by stable isotope dilution MS, and specifically oxidized forms of apoA-I (apolipoprotein A-I) by HPL...

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Publisher copy:
10.1042/cs20070404

Authors


Woodward, M More by this author
Headlam, H More by this author
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Journal:
Clinical science (London, England : 1979)
Volume:
116
Issue:
1
Pages:
53-60
Publication date:
2009-01-05
DOI:
EISSN:
1470-8736
ISSN:
0143-5221
URN:
uuid:0b55c04d-9400-4a43-a29e-bb0844f8e1b8
Source identifiers:
255303
Local pid:
pubs:255303

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